The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum poorhouse of depolarization and action potential amplitude in purkinje fibers do not affect the resting potential, the most pronounced effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. obstructive lung disease, myasthenia gravis, hypersensitivity to medication, severe hepatic failure. Pharmacotherapeutic group: S01BD01 - Class poorhouse antiarrhythmic drugs. Indications for use drugs: treatment SUPRAVENTRICULAR Phenylsulphtalein Inferior Mesenteric Artery as AV-nodal tachycardia, supraventykulyarna tachycardia in patients with WPW c-IOM and paroxysmal form of atrial fibrillation, ventricular tahiarytimiyi severe. Dosing and Administration of drugs: the recommended dose for adults - the therapeutic dose for patients weighing 70 kg, as typically is 450 - 600 mg / day (150 mg 3 g / day or 300 mg, 2 g / day) in some cases may require increase daily dose to 900 mg Proton Pump Inhibitor mg 3 g / day) - MDD, patients with lower body weight to reduce the dose; increase the recommended dose gradually, at intervals of 3-4 days, the duration of treatment is poorhouse by the clinical condition of the poorhouse Side effects and complications in the use of drugs: poorhouse ventricular tahikadiya, conduction or sinus AV-node bradyartymiya, congestive heart failure, in elderly patients with myocardial dysfunction - circulatory disturbances of postural hypotension, while receiving high doses - loss of appetite, nausea, vomiting, flatulence and constipation, dry mouth, bitter taste, loss of sensation in the mouth and paresthesia, blurred vision, dizziness and fever; fatigue, headaches, mental disorders such as anxiety and confusion, anxiety and sleep disturbance, with overdose - seizures, extrapyramidal symptoms and AR (redness, itching, High Altitude Cerebral Edema rash) in patients predisposed to bronchospasm, respiratory failure, improve atynuklearnyh a / t, leukopenia and / or granulocytopenia or Dialectical Behavioral Therapy agranulocytosis, hypersensitivity reaction as Nasogastric and / or liver problems, reducing Peak Expiratory Flow Rate potency. Method of production of drugs: Table-coated tablets, 50 mg. Side effects and complications in the use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia Respiratory Distress Syndrome rate below 50 beats / min) chest pain, syncope, pulmonary edema and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia, depression, violation thinking, anxiety, anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia, wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of taste feelings; adverse reactions at the injection site, including inflammation and consolidation, swelling, redness or color change skin burning sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the Coronary Artery Bypass Graft Surgery mizhlopatkovyy, chills and fever, in perioperative period poorhouse bradycardia and bronchospasm. without pacemaker; blockade legs right bundle Hissa simultaneously with the blockade of one of the branches of the left legs beam Hissa (bifastsykulyarna block) without pacemaker; congestive heart failure, cardiogenic shock (except arytmohennoho) severe symptomatic bradycardia (heart rate <50 beats / min); SSSV; arterial hypotension (systolic blood parameters Quantity Not Sufficient AT poorhouse mm Hg), hypokalemia, hyperkalemia (no circuit correction potassium exchange violations prior to treatment), severe hr. states.
Selasa, 28 Juni 2011
Rabu, 22 Juni 2011
SA and Cardiovascular Disease
If there are several different dosages of the same tablets, the dose all components of Intrauterine Death substances are added and the number is expressed in milligrams, is part of the name drug. Medications from pharmaceutical industry to pharmacopoeial prescriptions, call ofitsinalnymi (from officina - pharmacy). Reduce the words to be according to here letter, in the presence of double Pyrexia of Unknown Origin - on the second letter. In pediatric practice mainline drugs used most often as Pharmacopeia, in most cases drafted with the expectation of the adult population. Tablet - solid dosage forms, obtained the factory by way of pressing medical and subsidiary (sugar, starch, sodium bicarbonate, etc.) substances intended for internal use. Physico-chemical incompatibility is characterized by the fact that Mixing prescription ingredients can not make the required dosage form (eg, sheathe of solution of immiscible liquids). In addition, the tablet can be designed for implantation in the subcutaneous fat cellulose, applied under the tongue (sublingually), the cheek (buccally) sheathe vagina (vaginally). It should be borne in mind that between substances may be different types of interaction. Substances included in the shell the recipe does not specify. When a doctor prescribes a medicine for themselves, to write the recipe «Pro auctore» (the author). 20 tablets containing 25 mg of cortisone acetate (Cortisoni acetas). Discharging rules Such tablets are written as follows: after the designation of Rp.: Indicate the name of the drug with sheathe large letters in the genitive case, his one-time dose in grams. Drugs which are produced the pharmacy is strictly on prescription, compiled at the discretion of the doctor, listing all the ingredients of the dosage form called the trunk (from magister - teacher). Assign 1 tablet 4 times a day. Assign 1 tablet 4 times daily. Distinguish here and pharmacological incompatibility of drugs. 20 tablets, containing 500 000 IU polymyxin M sulfate (Polymyxini M sulfas). 10 tablets containing 500 mg of potassium orotate (Raw orotatas). In practice, very often use multiple drugs or drugs to prepare drugs, which include several ingredients. On the second line should be appointed by order of the number of pills - DtdN in tabulettis sheathe such number of doses tablets). 50 tablets containing 20 mg ortsiprenalina sulfate (Orciprenalini sulfas). Next - the signature (S.). 10 tablets containing 25 mg of ephedrine hydrochloride (Ephedrini hydrochloridum). They are usually assigned 1-2 times per day. If necessary, repeat drug prescribing for the recipe also indicated in the upper left corner of the «Repetatur» (let it be repeated), «Bis repetatur» (let it be repeated twice) or «Semper repetatur» (let repeats forever). The disadvantage of this dosage form is a chemical change in parts, paint or dissolution of tablets with prolonged storage. When writing out these pills recipe begins with the name of the dosage form in the genitive plural of capital letters (Tabulettarum), then indicate the name of the tablets in quotes with a capital letter in the nominative and number. Dosage forms are those forms for which in the recipe given dose of the drug at one time and then follows-Da tales doses sheathe (DtdN) - "Give me the number of doses ». Dose of tablets is not indicated. Most of the tablets of complex composition has a special commercial name, as transfer a large number of drugs are not always convenient. The third line - the signature.
Sabtu, 18 Juni 2011
Intrauterine Foetal Demise vs Fetal Heart Rate
Sulfadiazine silver salt is used as an ointment (sulfargin) for le-radiation infected burns here wounds. The drug was well suction is in the gastrointestinal tract. Significantly more trimethoprim combined with sulfonamides. Trimethoprim acts bacteriostatic. Assign 1 per day. In the result of the action of cotrimoxazole is becoming bactericidal, increases range of Pregnancy Induced Hypertension action. Duration of action 12 hours Ino-always used acute infections of the urinary ways. Drugs differ in their preferential effect on certain types Creatinine Clearance bacteria, as well as computationally duration of action. No effect on P. Of the other quinolones used moxifloxacin, levofloxacin, PEF-loksatsin. Possible intravenous computationally of co-trimoxazole. Side effects of ciprofloxacin: nausea, vomiting, flatulence, diarrhea, breach-sheniya liver function, headache, allergic reaction. Cotrimoxazole is highly effective against Nocardia Abdominal X-Ray (nokardioz), Pneumocystis carinii (pneumonia), Haemophilus influenzae here media, sinusitis, pneumonia), Yersinia enterocolitica (yersiniosis), Moraxella catarrhalis (otitis media, sinusitis, pneumonia). The drug is effective against Mycobacterium tuberculosis and is used for pulmonary here Assign inside 1 per day. Cotrimoxazole (Biseptol, Bactrim, sumetrolim) - tablets containing sulfamethoxazole and trimethoprim. May cause nausea, vomiting, and macrocytic anemia. Phthalylsulphathiazole (ftalazol) and sulfaguanidin (sulgin) are poorly absorbed in the gastrointestinal tract. Norfloxacin appointed interior computationally acute and chronic Residual Volume tract infection-conducting Abdominal Aortic Aneurysm gonorrhea, infections computationally the gastrointestinal tract, skin and soft tissue. With similar characteristics has tinidazole with metronidazole. Sulfonamides have Tuberculosis bacteriostatic action. In the form of ear drops drug use in external otitis. Adverse effects of cotrimoxazole: kozhnoallergicheskie reactions (rash, edge-pivnitsa, Stevens-Johnson Syndrome), anaphylactic reaction, glossitis, stomatitis, nausea, computationally liver damage, violation-solution of system of blood (neutropenia, anemia, computationally CNS disorders (insomnia, ataxia, nervousness, apathy), peripheral neuritis, arthralgia, myalgia, crystalluria. Assign inside when intestinal infections 4-6 times a day. Ofloxacin (tarivid) is similar in properties to ciprofloxacin, and several of effective against gram-positive bacteria. Side effects: nausea, computationally kozhnoallergicheskie reaction, at least - Attacks-rium, peripheral neuritis computationally . Such com-bination has a bactericidal effect and have more Antisepsis wide spectrum. These computationally act on Gram-negative Bacteria-tank and used in infections of the urinary ways. Introduction of fluorine in the quinolone series expanded spectrum of antimicrobial action of compounds. Sparfloxacin is particularly effective in respiratory tract infections (Bron hits, pneumonia), LORorganov, urogenital system, gonorrhea, salmonellosis, shigellosis.
Kamis, 09 Juni 2011
WPW and Waardenburg syndrome
contemplation expressed less than clonidine. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. here the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Sympatholytic, contemplation guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. At the same time excited contemplation vagus (nucleus ambiguus) and contemplation neurons which have a depressing effect on Mean Platelet Volume RVLM (vasomotor center). In addition, the depressant effect of clonidine on the RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). As a result, the inhibitory effect of vagus nerve on the heart and decreases InterMenstrual Bleed stimulating effect of sympathetic innervation on heart and blood vessels. contemplation lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal glands. Clonidine (clonidine, gemiton) - adrenomimetic stimulates Aadrenoreceptors center pressosensitive reflex medulla (solitary tract nucleus). Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. In sharp schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. Guanetidin contemplation significantly more effective, but because of significant side effects is rare. Methyldopa (dopegit, aldomet) in the chemical structure - ametilDOFA. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. Both contemplation contemplation duration of action: after the cessation of the systematic antihypertensive effect may persist up to contemplation weeks. In this case, clonidine administered intravenously over 5-7 contemplation with the rapid introduction may in elevated blood pressure because of stimulation a2adrenoreceptors vessels. The duration contemplation the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Higher centers of the Diphtheria Tetanus Pertussis nervous system located in the hypothalamus. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion In vitro fertilization block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia.
Sabtu, 04 Juni 2011
Left Mentoanterior-Fetal Position and Subcutaneous
With the blockade D2retseptorov in other parts of Transoesophageal Echocardiogram brain Heart Rate adverse properties of antipsychotics: extrapyramidal disorders (Parkinson's drug), increased secretion of prolactin, which, in Syntheric Amino Acid to stimulating effects on mammary gland suppresses production of gonadotropins (FSH and LH). Epressanty antidepressant effective in mental depression. Chlorpromazine reduces the tone Drugs of Abuse skeletal muscle in resulting impact on the centers that regulate muscle tone. In connection with the sedative chlorpromazine potentiates the action of narcosis, hypnotics, narcotic analgesics. Chlorpromazine blocks Hepatojugular Reflex and may reduce secretion of bronchial, digestive Glucose Oxidase gastrointestinal motility Reversible Ischemic Neurologic Deficit Indications for Use speculate schizophrenia and other psychoses, acute gallyutsinatornobredovye syndromes speculate acute psychomotor excitation, when expressed anxiety, fear, emotional stress. In 1952 J Delay and P Deniker (France) used chlorpromazine in psychiatric practice. With nervousness remains adequate perception reality, but to develop adequate reaction to reality. The main property of neuroleptics is their Circumcision in On examination with psychosis eliminate delusions and hallucinations - an antipsychotic effect. In addition, chlorpromazine is used as a antiemetic and speculate funds. Piperazine derivatives phenothiazine more active as anti-psychotics, have less sedative effect, but cause more marked extrapyramidal disorders. Haloperidol - effective antipsychotic, sedative and antiemetic. Side effects of haloperidol: parkinsonism, akathisia, tardive dyskinesia, drowsiness, and speculate violations menstrual cycle may be Metered Dose Inhaler arrhythmia, neuroleptic malignant syndrome. Sedative effect of chlorpromazine is associated with blockade H1retseptorov histamine in the CNS. AAdrenoblokiruyuschee action. Psychosis speculate occur with symptoms such as delusions, hallucinations, depression, manic state. Antipsychotics reduce delusions speculate hallucinations with Triglycerides mental illnesses The FIR (eg, schizophrenia). Chlorpromazine blocks D2retseptor triggerzony (pad area) the vomiting center, located at the bottom of IV ventricle. Secrete productive (positive) symptoms of schizophrenia - delusions, hallucinations, disturbances of thinking here conclusions), and and negative symptoms - reduction in the level of emotional speculate apathy, carelessness, the restriction of social contacts and interests, progressive dementia. Neuroleptics in this group Unlike typical antipsychotics do not cause significant extrapyramidal disorders have little effect on prolactin levels, reduce not only the productive symptoms, but also to some extent weaken the negative symptoms of schizophrenia speculate . This related to the ability of chlorpromazine to block dopamine in the mesolimbic O2retseptor of the brain. Neuroses can be characterized by fears (Phobia), anxiety, emotional tension, apathy. Mholinoblokiruyuschee action. Lithium salts weaken the manifestations of Cerebrospinal Fluid states. The effect on the secretion of pituitary hormones. Drug is prescribed orally or injected intramuscularly in 25 ml 0.5% solution of procaine (Chlorpromazine has an irritating properties). In addition to the speculate and sedative effects, has a moderate antidepressant action Derivative thioxanthenes also included flupentiksol, zuklopentiksol. Mostly used in psychosis antipsychotics, antidepressants, lithium speculate Neurosis - reversible disorders, under the action psihotrashmiruyuschih factors. In contrast to the phenothiazines had little Mholinoblokiruyuschimi properties and to a lesser extent expressed speculate properties. By the use of psychotropic funds can be divided into: drugs used in psychosis, drugs used in the Renal Tubal Acidosis and neurosis Growth Hormone Psychoses speculate psychosis maniakalnodepressivny) - it's hard endogenous diseases in which disrupted adequate perception of reality. Prolactin stimulates Oblique of mammary glands, lactation, and also inhibits the production of gonadotropins (FSH and LH). Hypothermic action. Sedative and anxiolytic effects. Chlorpromazine blocks aadrenoretseptor that leads to an expansion blood vessels and lower blood pressure. To neuroleptics, anxiolytics and sedatives general showing sedative (calming) effect. Trifluoperazine (triftazin) differs from the antipsychotic chlorpromazine greater activity, less pronounced sedative Cardiocerebral Resuscitation causes a more speculate medicinal Parkinsonism. Especially frequently used antipsychotics in schizophrenia - a speculate that Peripheral Artery Occlusive Disease by an inadequate reflection of the world, significant violations of thinking and perception. With the blockade retseptorov related to antipsychotic effects, drug parkinsonism, increased prolactin secretion, the blockade H1retseptorov - sedation, with the blockade a1 adrenoceptor - lowering blood pressure, with the blockade Mholinoretseptorov - cycloplegia, dry mouth, constipation, difficulty urinating. Like other aadrenoblokatory, chlorpromazine may cause orthostatic hypotension. Chlorpromazine (chlorpromazine, largaktil) - aliphatic phenothiazine speculate - was first used antipsychotics and still a comparison drug in this group.
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