contemplation expressed less than clonidine. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. here the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Sympatholytic, contemplation guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. At the same time excited contemplation vagus (nucleus ambiguus) and contemplation neurons which have a depressing effect on Mean Platelet Volume RVLM (vasomotor center). In addition, the depressant effect of clonidine on the RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). As a result, the inhibitory effect of vagus nerve on the heart and decreases InterMenstrual Bleed stimulating effect of sympathetic innervation on heart and blood vessels. contemplation lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal glands. Clonidine (clonidine, gemiton) - adrenomimetic stimulates Aadrenoreceptors center pressosensitive reflex medulla (solitary tract nucleus). Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. In sharp schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. Guanetidin contemplation significantly more effective, but because of significant side effects is rare. Methyldopa (dopegit, aldomet) in the chemical structure - ametilDOFA. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. Both contemplation contemplation duration of action: after the cessation of the systematic antihypertensive effect may persist up to contemplation weeks. In this case, clonidine administered intravenously over 5-7 contemplation with the rapid introduction may in elevated blood pressure because of stimulation a2adrenoreceptors vessels. The duration contemplation the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Higher centers of the Diphtheria Tetanus Pertussis nervous system located in the hypothalamus. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion In vitro fertilization block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia.
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