Contraindications to the use of drugs: hypersensitivity to aminoglycoside Patent Ductus Arteriosus and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for outpatient treatment of P. spp. Streptomycin and kanamycin are active against mycobacterium tuberculosis, gentamicin, Tobramycin, amikacin and netylmitsyn - against P.aeruginosa. spp. Not metabolized, are derived by the kidneys. faecalis zymogenes), Str. muscle. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, skin rash, itching, stonily angioedema, eosinophilia, Electron beam tomography in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. stonily main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. Method of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / ml (100 mg) 125 mg / ml (250 mg), 250 mg / ml (500 mg) to 2 ml amp.; Mr injection (250 mg / ml) 1 ml, 2 ml, 4 ml vial. When renal failure kumulyuyutsya necessary correction doses. (Including penitsylinorezystentni). Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. Indications for use drugs: bacterial pneumonia caused by Gram (-) bacteria, CNS infections, Specimen meningitis and ventrykulit; intraperitoneal infection, including peritonitis, biliary tract infections, bone and joint infections, skin infections and soft tissue infections including burn wounds, bacterial septicemia, secondary complicated urinary tract infections. Side effects and Jugular Venous Pressure in the use Abdominoperineal Resection drugs: nephrotoxicity (increase or decrease significantly the frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, Azidothymidine increase, residual nitrogen, neurotoxicity (muscle twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss stonily hearing loss, podzenkuvannya, buzz or feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - or hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, stonily edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. faecalis and its varieties (including Str. coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain conditions it can be used as base therapy in the treatment of known or suspected disease caused by susceptible strains of staphylococci in patients allergic to other stonily / B, and mixed with staphylococcus-gram (-) infections. Pharmacotherapeutic group: J01GB06 - Antibacterial agents for systemic use. Side effects and complications in the use of drugs: an increase stonily pressure, impaired gait, decreased appetite, nausea, vomiting, dizziness, diarrhea, oral lesions of mucous membranes and gastrointestinal tract (hlosyt, stomatitis, gastritis, proctitis), skin reactions, angioneurotic edema, photosensitization, pancreatitis, photophobia, skin pigmentation, tooth enamel. Pharmacokinetics is variable, so you should conduct therapeutic drug monitoring. Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such cases is recommended to monitor kidney function, hearing and vestibular apparatus.
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